翻译 Since 2012, a variety of enantioselective C-H functionalization reactions using Group 9 CpxM catalysts (M=Co, Rh, Ir) have been developed. Chiral Cpx ligand-based approaches have dominated this research field. These chiral catalysts generally exhibit high enantioselectivity owing to the well-designed persistent chiral environment around the reactive site. Other approaches, such as artificial metalloenzymes, chiral carboxylate-assisted enantioselective CMD, chiral carboxylic acid- or sulfonate-enabled enantioselective alkylation, and chiral TDG, have not been studied as extensively, but these conceptually different catalytic systems may provide new opportunities for synthetically useful reactions in the future. In these cases, general and rational designs of the chiral environment to achieve high enantioselectivity have not yet been established. A major research focus in coming years may be the establishment of such rational designs.
自2012年以来，使用第9族CpxM催化剂（M=钴、铑、铱）进行的多种对映选择性C-H官能化反应已经被开发出来。基于手性Cpx配体的方法在这一研究领域占据了主导地位。这些手性催化剂通常表现出高对映选择性，这是由于在反应位点周围精心设计的持久手性环境所致。其他方法，如人工金属酶、手性羧酸盐辅助的对映选择性CMD、手性羧酸或磺酸盐促进的对映选择性烷基化以及手性TDG，尚未被广泛研究，但这些概念上不同的催化系统可能在未来为合成有用的反应提供新的机会。在这些情况下，实现高对映选择性的手性环境的一般和合理设计尚未确立。未来几年的主要研究重点可能是建立这种合理的设计。