有机电合成技术在螺环化合物合成中的应用与优势

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问题:

翻译 Due to the diverse biological and pharmaceutical activities of spirocyclic compounds, many research groups are committed to studying efficient methods for the synthesis of spirocyclic compounds. Many of these methods require the use of transition metal catalysts, various halogenating agents, or harsh reaction conditions, and the synthetic process usually undergoes multicomponent cascade reactions, which are prone to side reactions leading to a decrease in yield. Organic electrosynthesis technology provides a concise and efficient method for the selective oxidation or reduction of organic molecules, which can also accomplish more complex multicomponent cascade reactions. In the electrochemical reaction, electrons replace the traditional redox reagents, which not only reduces the reaction cost, but also greatly reduces the number of byproducts, making the reaction environment friendly.8 In a complex multistep reaction process, perhaps the electrochemical reaction is just one step.

回答:

由于螺环化合物具有多样的生物和药物活性,许多研究团队致力于研究高效的螺环化合物合成方法。许多这些方法需要使用过渡金属催化剂、各种卤化剂或苛刻的反应条件,且合成过程通常经历多组分级联反应,容易产生副反应,导致产率下降。 有机电合成技术提供了一种简洁高效的方法,用于选择性氧化或还原有机分子,也可以完成更复杂的多组分级联反应。在电化学反应中,电子取代了传统的氧化还原试剂,这不仅降低了反应成本,还大大减少了副产物的数量,使反应更加环保。在复杂的多步反应过程中,电化学反应可能只是其中的一